diff --git a/config.h.meson b/config.h.meson
index 209b65d03c..ebafd3eac6 100644
--- a/config.h.meson
+++ b/config.h.meson
@@ -185,9 +185,6 @@
 /* Define to the sub-directory where libtool stores uninstalled libraries. */
 #mesondefine LT_OBJDIR
 
-/* Define if <X11/extensions/XIproto.h> needed for xReply */
-#mesondefine NEED_XIPROTO_H_FOR_XREPLY
-
 /* Define to 1 if your C compiler doesn't accept -c and -o together. */
 #mesondefine NO_MINUS_C_MINUS_O
 
diff --git a/gdk/x11/gdkasync.c b/gdk/x11/gdkasync.c
index fc4d94eaf5..1ef7697617 100644
--- a/gdk/x11/gdkasync.c
+++ b/gdk/x11/gdkasync.c
@@ -47,10 +47,6 @@ in this Software without prior written authorization from The Open Group.
 #include "gdkprivate-x11.h"
 #include "gdkdisplay-x11.h"
 
-#ifdef NEED_XIPROTO_H_FOR_XREPLY
-#include <X11/extensions/XIproto.h>
-#endif
-
 #include <X11/Xlibint.h>