diff --git a/fuzz/oss_fuzz/FuzzSKSL2SPIRV.cpp b/fuzz/oss_fuzz/FuzzSKSL2SPIRV.cpp
index d5a661df41..ba857778d1 100644
--- a/fuzz/oss_fuzz/FuzzSKSL2SPIRV.cpp
+++ b/fuzz/oss_fuzz/FuzzSKSL2SPIRV.cpp
@@ -15,6 +15,14 @@ bool FuzzSKSL2SPIRV(sk_sp<SkData> bytes) {
     SkSL::Compiler compiler(caps.get());
     SkSL::String output;
     SkSL::Program::Settings settings;
+
+    // This tells the compiler where the rt-flip uniform will live should it be required. For
+    // fuzzing purposes we don't care where that is, but the compiler will report an error if we
+    // leave them at their default invalid values, or if the offset overlaps another uniform.
+    settings.fRTFlipOffset  = 16384;
+    settings.fRTFlipSet     = 0;
+    settings.fRTFlipBinding = 0;
+
     std::unique_ptr<SkSL::Program> program = compiler.convertProgram(
                                                     SkSL::ProgramKind::kFragment,
                                                     SkSL::String((const char*) bytes->data(),
diff --git a/gn/sksl_tests.gni b/gn/sksl_tests.gni
index f43cc8e1a2..2c29eab92e 100644
--- a/gn/sksl_tests.gni
+++ b/gn/sksl_tests.gni
@@ -182,6 +182,7 @@ sksl_spirv_tests = [
   "/sksl/spirv/LayoutMultipleOf4.sksl",
   "/sksl/spirv/LayoutOutOfOrder.sksl",
   "/sksl/spirv/OpaqueTypeInArray.sksl",
+  "/sksl/spirv/Ossfuzz35916.sksl",
   "/sksl/workarounds/RewriteMatrixVectorMultiply.sksl",
   "/sksl/errors/Ossfuzz36850.sksl",
   "/sksl/errors/UndefinedFunction.sksl",
diff --git a/resources/sksl/spirv/Ossfuzz35916.sksl b/resources/sksl/spirv/Ossfuzz35916.sksl
new file mode 100644
index 0000000000..129c1b4959
--- /dev/null
+++ b/resources/sksl/spirv/Ossfuzz35916.sksl
@@ -0,0 +1,3 @@
+void main() {
+    sk_FragColor.x-- + sk_FragCoord;
+}
diff --git a/tests/sksl/spirv/Ossfuzz35916.asm.frag b/tests/sksl/spirv/Ossfuzz35916.asm.frag
new file mode 100644
index 0000000000..da115eb044
--- /dev/null
+++ b/tests/sksl/spirv/Ossfuzz35916.asm.frag
@@ -0,0 +1,69 @@
+OpCapability Shader
+%1 = OpExtInstImport "GLSL.std.450"
+OpMemoryModel Logical GLSL450
+OpEntryPoint Fragment %main "main" %sk_FragColor %sk_FragCoord %sk_Clockwise
+OpExecutionMode %main OriginUpperLeft
+OpName %sk_FragColor "sk_FragColor"
+OpName %sk_FragCoord "sk_FragCoord"
+OpName %sk_Clockwise "sk_Clockwise"
+OpName %main "main"
+OpName %sksl_synthetic_uniforms "sksl_synthetic_uniforms"
+OpMemberName %sksl_synthetic_uniforms 0 "u_skRTFlip"
+OpDecorate %sk_FragColor RelaxedPrecision
+OpDecorate %sk_FragColor Location 0
+OpDecorate %sk_FragColor Index 0
+OpDecorate %sk_FragCoord BuiltIn FragCoord
+OpDecorate %sk_Clockwise BuiltIn FrontFacing
+OpDecorate %19 RelaxedPrecision
+OpDecorate %21 RelaxedPrecision
+OpMemberDecorate %sksl_synthetic_uniforms 0 Offset 16384
+OpDecorate %sksl_synthetic_uniforms Block
+OpDecorate %22 Binding 0
+OpDecorate %22 DescriptorSet 0
+%float = OpTypeFloat 32
+%v4float = OpTypeVector %float 4
+%_ptr_Output_v4float = OpTypePointer Output %v4float
+%sk_FragColor = OpVariable %_ptr_Output_v4float Output
+%_ptr_Input_v4float = OpTypePointer Input %v4float
+%sk_FragCoord = OpVariable %_ptr_Input_v4float Input
+%bool = OpTypeBool
+%_ptr_Input_bool = OpTypePointer Input %bool
+%sk_Clockwise = OpVariable %_ptr_Input_bool Input
+%void = OpTypeVoid
+%13 = OpTypeFunction %void
+%_ptr_Output_float = OpTypePointer Output %float
+%int = OpTypeInt 32 1
+%int_0 = OpConstant %int 0
+%float_1 = OpConstant %float 1
+%v2float = OpTypeVector %float 2
+%sksl_synthetic_uniforms = OpTypeStruct %v2float
+%_ptr_Uniform_sksl_synthetic_uniforms = OpTypePointer Uniform %sksl_synthetic_uniforms
+%22 = OpVariable %_ptr_Uniform_sksl_synthetic_uniforms Uniform
+%_ptr_Uniform_v2float = OpTypePointer Uniform %v2float
+%main = OpFunction %void None %13
+%14 = OpLabel
+%15 = OpAccessChain %_ptr_Output_float %sk_FragColor %int_0
+%19 = OpLoad %float %15
+%21 = OpFSub %float %19 %float_1
+OpStore %15 %21
+%26 = OpLoad %v4float %sk_FragCoord
+%27 = OpCompositeExtract %float %26 0
+%28 = OpAccessChain %_ptr_Uniform_v2float %22 %int_0
+%30 = OpLoad %v2float %28
+%31 = OpCompositeExtract %float %30 0
+%32 = OpAccessChain %_ptr_Uniform_v2float %22 %int_0
+%33 = OpLoad %v2float %32
+%34 = OpCompositeExtract %float %33 1
+%35 = OpLoad %v4float %sk_FragCoord
+%36 = OpCompositeExtract %float %35 1
+%37 = OpFMul %float %34 %36
+%38 = OpFAdd %float %31 %37
+%39 = OpLoad %v4float %sk_FragCoord
+%40 = OpCompositeExtract %float %39 2
+%41 = OpLoad %v4float %sk_FragCoord
+%42 = OpCompositeExtract %float %41 3
+%43 = OpCompositeConstruct %v4float %27 %38 %40 %42
+%44 = OpCompositeConstruct %v4float %19 %19 %19 %19
+%45 = OpFAdd %v4float %44 %43
+OpReturn
+OpFunctionEnd