diff --git a/src/compiler/backend/instruction-selector.cc b/src/compiler/backend/instruction-selector.cc
index 50b4823665..1436bc0eec 100644
--- a/src/compiler/backend/instruction-selector.cc
+++ b/src/compiler/backend/instruction-selector.cc
@@ -1424,6 +1424,10 @@ void InstructionSelector::VisitNode(Node* node) {
       return VisitStore(node);
     case IrOpcode::kProtectedStore:
       return VisitProtectedStore(node);
+    case IrOpcode::kStoreLane: {
+      MarkAsRepresentation(MachineRepresentation::kSimd128, node);
+      return VisitStoreLane(node);
+    }
     case IrOpcode::kWord32And:
       return MarkAsWord32(node), VisitWord32And(node);
     case IrOpcode::kWord32Or:
@@ -2699,6 +2703,7 @@ void InstructionSelector::VisitI8x16Popcnt(Node* node) { UNIMPLEMENTED(); }
 #if !V8_TARGET_ARCH_X64
 // TODO(v8:10975): Prototyping load lane and store lane.
 void InstructionSelector::VisitLoadLane(Node* node) { UNIMPLEMENTED(); }
+void InstructionSelector::VisitStoreLane(Node* node) { UNIMPLEMENTED(); }
 
 // TODO(v8:10997) Prototype i64x2.bitmask.
 void InstructionSelector::VisitI64x2BitMask(Node* node) { UNIMPLEMENTED(); }
diff --git a/src/compiler/backend/x64/code-generator-x64.cc b/src/compiler/backend/x64/code-generator-x64.cc
index 30bd2a403e..35581151f2 100644
--- a/src/compiler/backend/x64/code-generator-x64.cc
+++ b/src/compiler/backend/x64/code-generator-x64.cc
@@ -3235,6 +3235,28 @@ CodeGenerator::CodeGenResult CodeGenerator::AssembleArchInstruction(
       __ Pextrb(dst, i.InputSimd128Register(0), i.InputUint8(1));
       break;
     }
+    case kX64Pextrb: {
+      EmitOOLTrapIfNeeded(zone(), this, opcode, instr, __ pc_offset());
+      DCHECK(HasAddressingMode(instr));
+      DCHECK(!instr->HasOutput());
+
+      size_t index = 0;
+      Operand operand = i.MemoryOperand(&index);
+      __ Pextrb(operand, i.InputSimd128Register(index),
+                i.InputUint8(index + 1));
+      break;
+    }
+    case kX64Pextrw: {
+      EmitOOLTrapIfNeeded(zone(), this, opcode, instr, __ pc_offset());
+      DCHECK(HasAddressingMode(instr));
+      DCHECK(!instr->HasOutput());
+
+      size_t index = 0;
+      Operand operand = i.MemoryOperand(&index);
+      __ Pextrw(operand, i.InputSimd128Register(index),
+                i.InputUint8(index + 1));
+      break;
+    }
     case kX64I8x16ExtractLaneS: {
       Register dst = i.OutputRegister();
       __ Pextrb(dst, i.InputSimd128Register(0), i.InputUint8(1));
@@ -3675,6 +3697,32 @@ CodeGenerator::CodeGenResult CodeGenerator::AssembleArchInstruction(
       __ Movq(i.OutputSimd128Register(), i.MemoryOperand());
       break;
     }
+    case kX64S128Store32Lane: {
+      EmitOOLTrapIfNeeded(zone(), this, opcode, instr, __ pc_offset());
+      size_t index = 0;
+      Operand operand = i.MemoryOperand(&index);
+      uint8_t lane = i.InputUint8(index + 1);
+      if (lane == 0) {
+        __ Movss(operand, i.InputSimd128Register(index));
+      } else {
+        DCHECK_GE(3, lane);
+        __ Extractps(operand, i.InputSimd128Register(index), lane);
+      }
+      break;
+    }
+    case kX64S128Store64Lane: {
+      EmitOOLTrapIfNeeded(zone(), this, opcode, instr, __ pc_offset());
+      size_t index = 0;
+      Operand operand = i.MemoryOperand(&index);
+      uint8_t lane = i.InputUint8(index + 1);
+      if (lane == 0) {
+        __ Movlps(operand, i.InputSimd128Register(index));
+      } else {
+        DCHECK_EQ(1, lane);
+        __ Movhps(operand, i.InputSimd128Register(index));
+      }
+      break;
+    }
     case kX64S32x4Swizzle: {
       DCHECK_EQ(2, instr->InputCount());
       ASSEMBLE_SIMD_IMM_INSTR(Pshufd, i.OutputSimd128Register(), 0,
diff --git a/src/compiler/backend/x64/instruction-codes-x64.h b/src/compiler/backend/x64/instruction-codes-x64.h
index 1ea0918ff6..593b0af3d9 100644
--- a/src/compiler/backend/x64/instruction-codes-x64.h
+++ b/src/compiler/backend/x64/instruction-codes-x64.h
@@ -281,6 +281,8 @@ namespace compiler {
   V(X64Pinsrw)                            \
   V(X64Pinsrd)                            \
   V(X64Pinsrq)                            \
+  V(X64Pextrb)                            \
+  V(X64Pextrw)                            \
   V(X64I8x16SConvertI16x8)                \
   V(X64I8x16Neg)                          \
   V(X64I8x16Shl)                          \
@@ -330,6 +332,8 @@ namespace compiler {
   V(X64S128Load32x2U)                     \
   V(X64S128LoadMem32Zero)                 \
   V(X64S128LoadMem64Zero)                 \
+  V(X64S128Store32Lane)                   \
+  V(X64S128Store64Lane)                   \
   V(X64S32x4Swizzle)                      \
   V(X64S32x4Shuffle)                      \
   V(X64S16x8Blend)                        \
diff --git a/src/compiler/backend/x64/instruction-scheduler-x64.cc b/src/compiler/backend/x64/instruction-scheduler-x64.cc
index 4225f44e84..a41e1bc8f7 100644
--- a/src/compiler/backend/x64/instruction-scheduler-x64.cc
+++ b/src/compiler/backend/x64/instruction-scheduler-x64.cc
@@ -348,8 +348,12 @@ int InstructionScheduler::GetTargetInstructionFlags(
 
     case kX64Movb:
     case kX64Movw:
+    case kX64S128Store32Lane:
+    case kX64S128Store64Lane:
       return kHasSideEffect;
 
+    case kX64Pextrb:
+    case kX64Pextrw:
     case kX64Movl:
       if (instr->HasOutput()) {
         DCHECK_LE(1, instr->InputCount());
diff --git a/src/compiler/backend/x64/instruction-selector-x64.cc b/src/compiler/backend/x64/instruction-selector-x64.cc
index 517d39bced..8b4db51529 100644
--- a/src/compiler/backend/x64/instruction-selector-x64.cc
+++ b/src/compiler/backend/x64/instruction-selector-x64.cc
@@ -7,6 +7,7 @@
 #include "src/base/iterator.h"
 #include "src/base/logging.h"
 #include "src/base/overflowing-math.h"
+#include "src/codegen/machine-type.h"
 #include "src/compiler/backend/instruction-selector-impl.h"
 #include "src/compiler/machine-operator.h"
 #include "src/compiler/node-matchers.h"
@@ -538,6 +539,40 @@ void InstructionSelector::VisitUnalignedLoad(Node* node) { UNREACHABLE(); }
 // Architecture supports unaligned access, therefore VisitStore is used instead
 void InstructionSelector::VisitUnalignedStore(Node* node) { UNREACHABLE(); }
 
+void InstructionSelector::VisitStoreLane(Node* node) {
+  X64OperandGenerator g(this);
+
+  StoreLaneParameters params = StoreLaneParametersOf(node->op());
+  InstructionCode opcode = kArchNop;
+  if (params.rep == MachineRepresentation::kWord8) {
+    opcode = kX64Pextrb;
+  } else if (params.rep == MachineRepresentation::kWord16) {
+    opcode = kX64Pextrw;
+  } else if (params.rep == MachineRepresentation::kWord32) {
+    opcode = kX64S128Store32Lane;
+  } else if (params.rep == MachineRepresentation::kWord64) {
+    opcode = kX64S128Store64Lane;
+  } else {
+    UNREACHABLE();
+  }
+
+  InstructionOperand inputs[4];
+  size_t input_count = 0;
+  AddressingMode addressing_mode =
+      g.GetEffectiveAddressMemoryOperand(node, inputs, &input_count);
+  opcode |= AddressingModeField::encode(addressing_mode);
+
+  if (params.kind == LoadKind::kProtected) {
+    opcode |= MiscField::encode(kMemoryAccessProtected);
+  }
+
+  InstructionOperand value_operand = g.UseRegister(node->InputAt(2));
+  inputs[input_count++] = value_operand;
+  inputs[input_count++] = g.UseImmediate(params.laneidx);
+  DCHECK_GE(4, input_count);
+  Emit(opcode, 0, nullptr, input_count, inputs);
+}
+
 // Shared routine for multiple binary operations.
 static void VisitBinop(InstructionSelector* selector, Node* node,
                        InstructionCode opcode, FlagsContinuation* cont) {
diff --git a/src/compiler/machine-operator.cc b/src/compiler/machine-operator.cc
index 649654010c..488594939e 100644
--- a/src/compiler/machine-operator.cc
+++ b/src/compiler/machine-operator.cc
@@ -141,6 +141,25 @@ UnalignedStoreRepresentation const& UnalignedStoreRepresentationOf(
   return OpParameter<UnalignedStoreRepresentation>(op);
 }
 
+size_t hash_value(StoreLaneParameters params) {
+  return base::hash_combine(params.kind, params.rep, params.laneidx);
+}
+
+std::ostream& operator<<(std::ostream& os, StoreLaneParameters params) {
+  return os << "(" << params.kind << " " << params.rep << " " << params.laneidx
+            << ")";
+}
+
+StoreLaneParameters const& StoreLaneParametersOf(Operator const* op) {
+  DCHECK_EQ(IrOpcode::kStoreLane, op->opcode());
+  return OpParameter<StoreLaneParameters>(op);
+}
+
+bool operator==(StoreLaneParameters lhs, StoreLaneParameters rhs) {
+  return lhs.kind == rhs.kind && lhs.rep == rhs.rep &&
+         lhs.laneidx == rhs.laneidx;
+}
+
 bool operator==(StackSlotRepresentation lhs, StackSlotRepresentation rhs) {
   return lhs.size() == rhs.size() && lhs.alignment() == rhs.alignment();
 }
@@ -821,6 +840,15 @@ struct ProtectedStoreOperator : public Operator1<StoreRepresentation> {
                   StoreRepresentation(rep, kNoWriteBarrier)) {}
 };
 
+template <LoadKind kind, MachineRepresentation rep, uint8_t laneidx>
+struct StoreLaneOperator : public Operator1<StoreLaneParameters> {
+  StoreLaneOperator()
+      : Operator1(IrOpcode::kStoreLane,
+                  Operator::kNoDeopt | Operator::kNoRead | Operator::kNoThrow,
+                  "StoreLane", 3, 1, 1, 0, 1, 0,
+                  StoreLaneParameters{kind, rep, laneidx}) {}
+};
+
 template <MachineRepresentation rep, MachineSemantic sem>
 struct Word32AtomicLoadOperator : public Operator1<LoadRepresentation> {
   Word32AtomicLoadOperator()
@@ -1200,6 +1228,39 @@ const Operator* MachineOperatorBuilder::LoadLane(LoadKind kind,
   UNREACHABLE();
 }
 
+const Operator* MachineOperatorBuilder::StoreLane(LoadKind kind,
+                                                  MachineRepresentation rep,
+                                                  uint8_t laneidx) {
+#define STORE_LANE_KIND(REP, KIND, LANEIDX)                             \
+  if (kind == LoadKind::k##KIND && rep == MachineRepresentation::REP && \
+      laneidx == LANEIDX) {                                             \
+    return GetCachedOperator<StoreLaneOperator<                         \
+        LoadKind::k##KIND, MachineRepresentation::REP, LANEIDX>>();     \
+  }
+
+#define STORE_LANE_T(T, LANE)         \
+  STORE_LANE_KIND(T, Normal, LANE)    \
+  STORE_LANE_KIND(T, Unaligned, LANE) \
+  STORE_LANE_KIND(T, Protected, LANE)
+
+#define STORE_LANE_WORD8(LANE) STORE_LANE_T(kWord8, LANE)
+#define STORE_LANE_WORD16(LANE) STORE_LANE_T(kWord16, LANE)
+#define STORE_LANE_WORD32(LANE) STORE_LANE_T(kWord32, LANE)
+#define STORE_LANE_WORD64(LANE) STORE_LANE_T(kWord64, LANE)
+
+  // Semicolons unnecessary, but helps formatting.
+  SIMD_I8x16_LANES(STORE_LANE_WORD8);
+  SIMD_I16x8_LANES(STORE_LANE_WORD16);
+  SIMD_I32x4_LANES(STORE_LANE_WORD32);
+  SIMD_I64x2_LANES(STORE_LANE_WORD64);
+#undef STORE_LANE_WORD8
+#undef STORE_LANE_WORD16
+#undef STORE_LANE_WORD32
+#undef STORE_LANE_WORD64
+#undef STORE_LANE_KIND
+  UNREACHABLE();
+}
+
 const Operator* MachineOperatorBuilder::StackSlot(int size, int alignment) {
   DCHECK_LE(0, size);
   DCHECK(alignment == 0 || alignment == 4 || alignment == 8 || alignment == 16);
diff --git a/src/compiler/machine-operator.h b/src/compiler/machine-operator.h
index f4b6b3190d..9eaab56a17 100644
--- a/src/compiler/machine-operator.h
+++ b/src/compiler/machine-operator.h
@@ -49,6 +49,7 @@ using LoadRepresentation = MachineType;
 V8_EXPORT_PRIVATE LoadRepresentation LoadRepresentationOf(Operator const*)
     V8_WARN_UNUSED_RESULT;
 
+// TODO(zhin): This is used by StoreLane too, rename this.
 enum class LoadKind {
   kNormal,
   kUnaligned,
@@ -135,6 +136,17 @@ using UnalignedStoreRepresentation = MachineRepresentation;
 UnalignedStoreRepresentation const& UnalignedStoreRepresentationOf(
     Operator const*) V8_WARN_UNUSED_RESULT;
 
+struct StoreLaneParameters {
+  LoadKind kind;
+  MachineRepresentation rep;
+  uint8_t laneidx;
+};
+
+V8_EXPORT_PRIVATE std::ostream& operator<<(std::ostream&, StoreLaneParameters);
+
+V8_EXPORT_PRIVATE StoreLaneParameters const& StoreLaneParametersOf(
+    Operator const*) V8_WARN_UNUSED_RESULT;
+
 class StackSlotRepresentation final {
  public:
   StackSlotRepresentation(int size, int alignment)
@@ -801,6 +813,10 @@ class V8_EXPORT_PRIVATE MachineOperatorBuilder final
   const Operator* Store(StoreRepresentation rep);
   const Operator* ProtectedStore(MachineRepresentation rep);
 
+  // SIMD store: store a specified lane of value into [base + index].
+  const Operator* StoreLane(LoadKind kind, MachineRepresentation rep,
+                            uint8_t laneidx);
+
   // unaligned load [base + index]
   const Operator* UnalignedLoad(LoadRepresentation rep);
 
diff --git a/src/compiler/opcodes.h b/src/compiler/opcodes.h
index 474a09a917..865775c81a 100644
--- a/src/compiler/opcodes.h
+++ b/src/compiler/opcodes.h
@@ -959,7 +959,8 @@
   V(V8x16AnyTrue)               \
   V(V8x16AllTrue)               \
   V(LoadTransform)              \
-  V(LoadLane)
+  V(LoadLane)                   \
+  V(StoreLane)
 
 #define VALUE_OP_LIST(V)  \
   COMMON_OP_LIST(V)       \
diff --git a/src/compiler/wasm-compiler.cc b/src/compiler/wasm-compiler.cc
index 1bb91420e8..9f48e0803a 100644
--- a/src/compiler/wasm-compiler.cc
+++ b/src/compiler/wasm-compiler.cc
@@ -16,6 +16,7 @@
 #include "src/codegen/code-factory.h"
 #include "src/codegen/compiler.h"
 #include "src/codegen/interface-descriptors.h"
+#include "src/codegen/machine-type.h"
 #include "src/codegen/optimized-compilation-info.h"
 #include "src/compiler/backend/code-generator.h"
 #include "src/compiler/backend/instruction-selector.h"
@@ -4110,6 +4111,37 @@ Node* WasmGraphBuilder::LoadMem(wasm::ValueType type, MachineType memtype,
   return load;
 }
 
+Node* WasmGraphBuilder::StoreLane(MachineRepresentation mem_rep, Node* index,
+                                  uint32_t offset, uint32_t alignment,
+                                  Node* val, uint8_t laneidx,
+                                  wasm::WasmCodePosition position,
+                                  wasm::ValueType type) {
+  Node* store;
+  has_simd_ = true;
+  index = BoundsCheckMem(i::ElementSizeInBytes(mem_rep), index, offset,
+                         position, kCanOmitBoundsCheck);
+
+  MachineType memtype = MachineType(mem_rep, MachineSemantic::kNone);
+  LoadKind load_kind = GetLoadKind(mcgraph(), memtype, use_trap_handler());
+
+  // {offset} is validated to be within uintptr_t range in {BoundsCheckMem}.
+  uintptr_t capped_offset = static_cast<uintptr_t>(offset);
+
+  store = SetEffect(graph()->NewNode(
+      mcgraph()->machine()->StoreLane(load_kind, mem_rep, laneidx),
+      MemBuffer(capped_offset), index, val, effect(), control()));
+
+  if (load_kind == LoadKind::kProtected) {
+    SetSourcePosition(store, position);
+  }
+
+  if (FLAG_trace_wasm_memory) {
+    TraceMemoryOperation(true, mem_rep, index, capped_offset, position);
+  }
+
+  return store;
+}
+
 Node* WasmGraphBuilder::StoreMem(MachineRepresentation mem_rep, Node* index,
                                  uint64_t offset, uint32_t alignment, Node* val,
                                  wasm::WasmCodePosition position,
diff --git a/src/compiler/wasm-compiler.h b/src/compiler/wasm-compiler.h
index d4c2245271..967d75edab 100644
--- a/src/compiler/wasm-compiler.h
+++ b/src/compiler/wasm-compiler.h
@@ -325,6 +325,9 @@ class WasmGraphBuilder {
   Node* StoreMem(MachineRepresentation mem_rep, Node* index, uint64_t offset,
                  uint32_t alignment, Node* val, wasm::WasmCodePosition position,
                  wasm::ValueType type);
+  Node* StoreLane(MachineRepresentation mem_rep, Node* index, uint32_t offset,
+                  uint32_t alignment, Node* val, uint8_t laneidx,
+                  wasm::WasmCodePosition position, wasm::ValueType type);
   static void PrintDebugName(Node* node);
 
   void set_instance_node(Node* instance_node) {
diff --git a/src/wasm/baseline/liftoff-compiler.cc b/src/wasm/baseline/liftoff-compiler.cc
index 3c647f840f..61e6d9fc5e 100644
--- a/src/wasm/baseline/liftoff-compiler.cc
+++ b/src/wasm/baseline/liftoff-compiler.cc
@@ -2374,6 +2374,12 @@ class LiftoffCompiler {
     }
   }
 
+  void StoreLane(FullDecoder* decoder, StoreType type,
+                 const MemoryAccessImmediate<validate>& imm, const Value& index,
+                 const Value& value, const uint8_t laneidx) {
+    unsupported(decoder, kSimd, "simd load lane");
+  }
+
   void CurrentMemoryPages(FullDecoder* decoder, Value* result) {
     Register mem_size = __ GetUnusedRegister(kGpReg, {}).gp();
     LOAD_INSTANCE_FIELD(mem_size, MemorySize, kSystemPointerSize);
diff --git a/src/wasm/function-body-decoder-impl.h b/src/wasm/function-body-decoder-impl.h
index caef9aea91..bfe7ed69ab 100644
--- a/src/wasm/function-body-decoder-impl.h
+++ b/src/wasm/function-body-decoder-impl.h
@@ -983,6 +983,8 @@ struct ControlBase : public PcForErrors<validate> {
     Value* result)                                                             \
   F(StoreMem, StoreType type, const MemoryAccessImmediate<validate>& imm,      \
     const Value& index, const Value& value)                                    \
+  F(StoreLane, StoreType type, const MemoryAccessImmediate<validate>& imm,     \
+    const Value& index, const Value& value, const uint8_t laneidx)             \
   F(CurrentMemoryPages, Value* result)                                         \
   F(MemoryGrow, const Value& value, Value* result)                             \
   F(CallDirect, const CallFunctionImmediate<validate>& imm,                    \
@@ -1749,7 +1751,11 @@ class WasmDecoder : public Decoder {
           case kExprS128Load8Lane:
           case kExprS128Load16Lane:
           case kExprS128Load32Lane:
-          case kExprS128Load64Lane: {
+          case kExprS128Load64Lane:
+          case kExprS128Store8Lane:
+          case kExprS128Store16Lane:
+          case kExprS128Store32Lane:
+          case kExprS128Store64Lane: {
             MemoryAccessImmediate<validate> imm(decoder, pc + length,
                                                 UINT32_MAX);
             // 1 more byte for lane index immediate.
@@ -3334,6 +3340,20 @@ class WasmFullDecoder : public WasmDecoder<validate> {
     return opcode_length + mem_imm.length + lane_imm.length;
   }
 
+  int DecodeStoreLane(StoreType type, uint32_t opcode_length) {
+    if (!CheckHasMemory()) return 0;
+    MemoryAccessImmediate<validate> mem_imm(this, this->pc_ + opcode_length,
+                                            type.size_log_2());
+    SimdLaneImmediate<validate> lane_imm(
+        this, this->pc_ + opcode_length + mem_imm.length);
+    Value v128 = Pop(1, kWasmS128);
+    Value index = Pop(0, kWasmI32);
+
+    CALL_INTERFACE_IF_REACHABLE(StoreLane, type, mem_imm, index, v128,
+                                lane_imm.lane);
+    return opcode_length + mem_imm.length + lane_imm.length;
+  }
+
   int DecodeStoreMem(StoreType store, int prefix_len = 1) {
     if (!CheckHasMemory()) return 0;
     MemoryAccessImmediate<validate> imm(this, this->pc_ + prefix_len,
@@ -3578,6 +3598,18 @@ class WasmFullDecoder : public WasmDecoder<validate> {
       case kExprS128Load64Lane: {
         return DecodeLoadLane(LoadType::kI64Load, opcode_length);
       }
+      case kExprS128Store8Lane: {
+        return DecodeStoreLane(StoreType::kI32Store8, opcode_length);
+      }
+      case kExprS128Store16Lane: {
+        return DecodeStoreLane(StoreType::kI32Store16, opcode_length);
+      }
+      case kExprS128Store32Lane: {
+        return DecodeStoreLane(StoreType::kI32Store, opcode_length);
+      }
+      case kExprS128Store64Lane: {
+        return DecodeStoreLane(StoreType::kI64Store, opcode_length);
+      }
       case kExprS128Const:
         return SimdConstOp(opcode_length);
       default: {
diff --git a/src/wasm/graph-builder-interface.cc b/src/wasm/graph-builder-interface.cc
index 984dd935e8..f6bb870980 100644
--- a/src/wasm/graph-builder-interface.cc
+++ b/src/wasm/graph-builder-interface.cc
@@ -450,6 +450,13 @@ class WasmGraphBuildingInterface {
           value.node, decoder->position(), type.value_type());
   }
 
+  void StoreLane(FullDecoder* decoder, StoreType type,
+                 const MemoryAccessImmediate<validate>& imm, const Value& index,
+                 const Value& value, const uint8_t laneidx) {
+    BUILD(StoreLane, type.mem_rep(), index.node, imm.offset, imm.alignment,
+          value.node, laneidx, decoder->position(), type.value_type());
+  }
+
   void CurrentMemoryPages(FullDecoder* decoder, Value* result) {
     result->node = BUILD(CurrentMemoryPages);
   }
diff --git a/src/wasm/wasm-opcodes-inl.h b/src/wasm/wasm-opcodes-inl.h
index 5b50f1cd47..76901115ec 100644
--- a/src/wasm/wasm-opcodes-inl.h
+++ b/src/wasm/wasm-opcodes-inl.h
@@ -313,6 +313,10 @@ constexpr const char* WasmOpcodes::OpcodeName(WasmOpcode opcode) {
     CASE_S128_OP(Load16Lane, "load16_lane")
     CASE_S128_OP(Load32Lane, "load32_lane")
     CASE_S128_OP(Load64Lane, "load64_lane")
+    CASE_S128_OP(Store8Lane, "store8_lane")
+    CASE_S128_OP(Store16Lane, "store16_lane")
+    CASE_S128_OP(Store32Lane, "store32_lane")
+    CASE_S128_OP(Store64Lane, "store64_lane")
 
     CASE_I8x16_OP(RoundingAverageU, "avgr_u")
     CASE_I16x8_OP(RoundingAverageU, "avgr_u")
diff --git a/src/wasm/wasm-opcodes.h b/src/wasm/wasm-opcodes.h
index e150b67176..e8908cd6d7 100644
--- a/src/wasm/wasm-opcodes.h
+++ b/src/wasm/wasm-opcodes.h
@@ -465,7 +465,11 @@ bool V8_EXPORT_PRIVATE IsJSCompatibleSignature(const FunctionSig* sig,
   V(S128Load8Lane, 0xfd58, s_is)            \
   V(S128Load16Lane, 0xfd59, s_is)           \
   V(S128Load32Lane, 0xfd5a, s_is)           \
-  V(S128Load64Lane, 0xfd5b, s_is)
+  V(S128Load64Lane, 0xfd5b, s_is)           \
+  V(S128Store8Lane, 0xfd5c, v_is)           \
+  V(S128Store16Lane, 0xfd5d, v_is)          \
+  V(S128Store32Lane, 0xfd5e, v_is)          \
+  V(S128Store64Lane, 0xfd5f, v_is)
 
 #define FOREACH_SIMD_POST_MVP_OPCODE(V)  \
   V(I8x16Mul, 0xfd75, s_ss)              \
diff --git a/test/cctest/wasm/test-run-wasm-simd.cc b/test/cctest/wasm/test-run-wasm-simd.cc
index 48614264c9..5f620e25ed 100644
--- a/test/cctest/wasm/test-run-wasm-simd.cc
+++ b/test/cctest/wasm/test-run-wasm-simd.cc
@@ -3688,6 +3688,81 @@ WASM_SIMD_TEST_NO_LOWERING(S128Load64Lane) {
   RunLoadLaneTest<int64_t>(execution_tier, lower_simd, kExprS128Load64Lane,
                            kExprI64x2Splat);
 }
+
+template <typename T>
+void RunStoreLaneTest(TestExecutionTier execution_tier, LowerSimd lower_simd,
+                      WasmOpcode store_op, WasmOpcode splat_op) {
+  FLAG_SCOPE(wasm_simd_post_mvp);
+  if (execution_tier == TestExecutionTier::kLiftoff) {
+    // Not yet implemented.
+    return;
+  }
+
+  constexpr int lanes = kSimd128Size / sizeof(T);
+  constexpr int mem_index = 16;  // Store from mem index 16 (bytes).
+  constexpr int splat_value = 33;
+  WasmOpcode const_op =
+      splat_op == kExprI64x2Splat ? kExprI64Const : kExprI32Const;
+
+  for (int lane_index = 0; lane_index < lanes; lane_index++) {
+    WasmRunner<int32_t> r(execution_tier, lower_simd);
+    T* memory = r.builder().AddMemoryElems<T>(kWasmPageSize / sizeof(T));
+
+    // Splat splat_value, then only Store and replace a single lane with the
+    BUILD(r, WASM_I32V(mem_index), const_op, splat_value,
+          WASM_SIMD_OP(splat_op), WASM_SIMD_OP(store_op), ZERO_ALIGNMENT,
+          ZERO_OFFSET, lane_index, WASM_ONE);
+
+    r.builder().BlankMemory();
+    r.Call();
+
+    for (int i = 0; i < lanes; i++) {
+      CHECK_EQ(0, r.builder().ReadMemory(&memory[i]));
+    }
+
+    CHECK_EQ(splat_value, r.builder().ReadMemory(&memory[lanes]));
+
+    for (int i = lanes + 1; i < lanes * 2; i++) {
+      CHECK_EQ(0, r.builder().ReadMemory(&memory[i]));
+    }
+  }
+
+  // OOB stores
+  {
+    WasmRunner<int32_t, uint32_t> r(execution_tier, lower_simd);
+    r.builder().AddMemoryElems<T>(kWasmPageSize / sizeof(T));
+
+    BUILD(r, WASM_GET_LOCAL(0), const_op, splat_value, WASM_SIMD_OP(splat_op),
+          WASM_SIMD_OP(store_op), ZERO_ALIGNMENT, ZERO_OFFSET, 0, WASM_ONE);
+
+    // StoreLane stores sizeof(T) bytes.
+    for (uint32_t index = kWasmPageSize - (sizeof(T) - 1);
+         index < kWasmPageSize; ++index) {
+      CHECK_TRAP(r.Call(index));
+    }
+  }
+}
+
+WASM_SIMD_TEST_NO_LOWERING(S128Store8Lane) {
+  RunStoreLaneTest<int8_t>(execution_tier, lower_simd, kExprS128Store8Lane,
+                           kExprI8x16Splat);
+}
+
+WASM_SIMD_TEST_NO_LOWERING(S128Store16Lane) {
+  RunStoreLaneTest<int16_t>(execution_tier, lower_simd, kExprS128Store16Lane,
+                            kExprI16x8Splat);
+}
+
+WASM_SIMD_TEST_NO_LOWERING(S128Store32Lane) {
+  RunStoreLaneTest<int32_t>(execution_tier, lower_simd, kExprS128Store32Lane,
+                            kExprI32x4Splat);
+}
+
+WASM_SIMD_TEST_NO_LOWERING(S128Store64Lane) {
+  RunStoreLaneTest<int64_t>(execution_tier, lower_simd, kExprS128Store64Lane,
+                            kExprI64x2Splat);
+}
+
 #endif  // V8_TARGET_ARCH_X64
 
 #define WASM_SIMD_ANYTRUE_TEST(format, lanes, max, param_type)                \
diff --git a/test/common/wasm/wasm-interpreter.cc b/test/common/wasm/wasm-interpreter.cc
index 72991a775a..c3caa9fd71 100644
--- a/test/common/wasm/wasm-interpreter.cc
+++ b/test/common/wasm/wasm-interpreter.cc
@@ -2692,6 +2692,22 @@ class WasmInterpreterInternals {
         return DoSimdLoadLane<int2, int64_t, int64_t>(
             decoder, code, pc, len, MachineRepresentation::kWord64);
       }
+      case kExprS128Store8Lane: {
+        return DoSimdStoreLane<int16, int32_t, int8_t>(
+            decoder, code, pc, len, MachineRepresentation::kWord8);
+      }
+      case kExprS128Store16Lane: {
+        return DoSimdStoreLane<int8, int32_t, int16_t>(
+            decoder, code, pc, len, MachineRepresentation::kWord16);
+      }
+      case kExprS128Store32Lane: {
+        return DoSimdStoreLane<int4, int32_t, int32_t>(
+            decoder, code, pc, len, MachineRepresentation::kWord32);
+      }
+      case kExprS128Store64Lane: {
+        return DoSimdStoreLane<int2, int64_t, int64_t>(
+            decoder, code, pc, len, MachineRepresentation::kWord64);
+      }
       default:
         return false;
     }
@@ -2770,6 +2786,30 @@ class WasmInterpreterInternals {
     return true;
   }
 
+  template <typename s_type, typename result_type, typename load_type>
+  bool DoSimdStoreLane(Decoder* decoder, InterpreterCode* code, pc_t pc,
+                       int* const len, MachineRepresentation rep) {
+    // Extract a single lane, push it onto the stack, then store the lane.
+    s_type value = Pop().to_s128().to<s_type>();
+
+    MemoryAccessImmediate<Decoder::kNoValidation> imm(
+        decoder, code->at(pc + *len), sizeof(load_type));
+
+    SimdLaneImmediate<Decoder::kNoValidation> lane_imm(
+        decoder, code->at(pc + *len + imm.length));
+
+    Push(WasmValue(value.val[LANE(lane_imm.lane, value)]));
+
+    // ExecuteStore will update the len, so pass it unchanged here.
+    if (!ExecuteStore<result_type, load_type>(decoder, code, pc, len, rep,
+                                              /*prefix_len=*/*len)) {
+      return false;
+    }
+
+    *len += lane_imm.length;
+    return true;
+  }
+
   // Check if our control stack (frames_) exceeds the limit. Trigger stack
   // overflow if it does, and unwinding the current frame.
   // Returns true if execution can continue, false if the stack was fully