diff --git a/src/compiler/js-builtin-reducer.cc b/src/compiler/js-builtin-reducer.cc
index 66c212dfcb..40aaef91f9 100644
--- a/src/compiler/js-builtin-reducer.cc
+++ b/src/compiler/js-builtin-reducer.cc
@@ -1513,6 +1513,11 @@ Reduction JSBuiltinReducer::ReduceNumberIsInteger(Node* node) {
 // ES6 section 20.1.2.4 Number.isNaN ( number )
 Reduction JSBuiltinReducer::ReduceNumberIsNaN(Node* node) {
   JSCallReduction r(node);
+  if (r.InputsMatchZero()) {
+    // Number.isNaN() -> #false
+    Node* value = jsgraph()->FalseConstant();
+    return Replace(value);
+  }
   // Number.isNaN(a:number) -> ObjectIsNaN(a)
   Node* input = r.GetJSCallInput(0);
   Node* value = graph()->NewNode(simplified()->ObjectIsNaN(), input);
diff --git a/test/mjsunit/regress/regress-6082.js b/test/mjsunit/regress/regress-6082.js
new file mode 100644
index 0000000000..aec1be0fb7
--- /dev/null
+++ b/test/mjsunit/regress/regress-6082.js
@@ -0,0 +1,11 @@
+// Copyright 2017 the V8 project authors. All rights reserved.
+// Use of this source code is governed by a BSD-style license that can be
+// found in the LICENSE file.
+
+// Flags: --allow-natives-syntax
+
+function foo() { return Number.isNaN(); }
+assertFalse(foo());
+assertFalse(foo());
+%OptimizeFunctionOnNextCall(foo);
+assertFalse(foo());