diff --git a/src/flag-definitions.h b/src/flag-definitions.h
index edbe4ebab7..870aed86bd 100644
--- a/src/flag-definitions.h
+++ b/src/flag-definitions.h
@@ -404,15 +404,16 @@ DEFINE_BOOL(omit_map_checks_for_leaf_maps, true,
 
 // Flags for TurboFan.
 DEFINE_BOOL(turbo, false, "enable TurboFan compiler")
+DEFINE_IMPLICATION(turbo, turbo_asm_deoptimization)
+DEFINE_IMPLICATION(turbo, turbo_inlining)
 DEFINE_BOOL(turbo_shipping, true, "enable TurboFan compiler on subset")
 DEFINE_BOOL(turbo_greedy_regalloc, false, "use the greedy register allocator")
 DEFINE_BOOL(turbo_preprocess_ranges, true,
             "run pre-register allocation heuristics")
 DEFINE_BOOL(turbo_loop_stackcheck, true, "enable stack checks in loops")
-
-DEFINE_IMPLICATION(turbo, turbo_asm_deoptimization)
 DEFINE_STRING(turbo_filter, "~~", "optimization filter for TurboFan compiler")
 DEFINE_BOOL(trace_turbo, false, "trace generated TurboFan IR")
+DEFINE_IMPLICATION(trace_turbo, turbo_source_positions)
 DEFINE_BOOL(trace_turbo_graph, false, "trace generated TurboFan graphs")
 DEFINE_IMPLICATION(trace_turbo_graph, trace_turbo)
 DEFINE_STRING(trace_turbo_cfg_file, NULL,
@@ -432,7 +433,6 @@ DEFINE_BOOL(turbo_types, true, "use typed lowering in TurboFan")
 DEFINE_BOOL(turbo_type_feedback, false, "use type feedback in TurboFan")
 DEFINE_BOOL(turbo_source_positions, false,
             "track source code positions when building TurboFan IR")
-DEFINE_IMPLICATION(trace_turbo, turbo_source_positions)
 DEFINE_BOOL(function_context_specialization, false,
             "enable function context specialization in TurboFan")
 DEFINE_BOOL(native_context_specialization, true,
diff --git a/test/cctest/cctest.status b/test/cctest/cctest.status
index 92627ac3d8..ccfc813ec4 100644
--- a/test/cctest/cctest.status
+++ b/test/cctest/cctest.status
@@ -120,6 +120,13 @@
   'test-debug/ScriptBreakPointByIdThroughJavaScript': [PASS, NO_VARIANTS],
   'test-debug/ScriptBreakPointByNameThroughJavaScript': [PASS, NO_VARIANTS],
 
+  # Issue 4493: Open issues before we can ship general purpose inlining.
+  'test-decls/CrossScriptGlobal': [PASS, NO_VARIANTS],
+  'test-decls/CrossScriptReferencesHarmony': [PASS, NO_VARIANTS],
+  'test-decls/CrossScriptLoadICs': [PASS, NO_VARIANTS],
+  'test-decls/CrossScriptStoreICs': [PASS, NO_VARIANTS],
+  'test-decls/Regress3941': [PASS, NO_VARIANTS],
+
   ############################################################################
   # Slow tests.
   'test-api/Threading1': [PASS, ['mode == debug', SLOW]],
diff --git a/test/mjsunit/mjsunit.status b/test/mjsunit/mjsunit.status
index 595fc6f4c1..76c323c4dd 100644
--- a/test/mjsunit/mjsunit.status
+++ b/test/mjsunit/mjsunit.status
@@ -152,6 +152,24 @@
   # TODO(titzer): too slow in --turbo mode due to O(n^2) graph verification.
   'regress/regress-1122': [PASS, NO_VARIANTS],
 
+  # Issue 4493: Open issues before we can ship general purpose inlining.
+  'array-reduce': [PASS, NO_VARIANTS],
+  'compiler/lazy-deopt-in-literal': [PASS, NO_VARIANTS],
+  'compiler/osr-infinite': [PASS, NO_VARIANTS],
+  'es6/array-find': [PASS, NO_VARIANTS],
+  'es6/array-findindex': [PASS, NO_VARIANTS],
+  'es6/microtask-delivery': [PASS, NO_VARIANTS],
+  'es6/promises': [PASS, NO_VARIANTS],  # only on 64-bit.
+  'es6/templates': [PASS, NO_VARIANTS],
+  'es6/typedarray-find': [PASS, NO_VARIANTS],
+  'es6/typedarray-findindex': [PASS, NO_VARIANTS],
+  'harmony/destructuring': [PASS, NO_VARIANTS],
+  'harmony/proxies': [PASS, NO_VARIANTS],
+  'harmony/proxies-example-membrane': [PASS, NO_VARIANTS],  # only on 64-bit.
+  'harmony/spread-array': [PASS, NO_VARIANTS],
+  'regress/cross-script-vars': [PASS, NO_VARIANTS],
+  'tools/profile': [PASS, NO_VARIANTS],
+
   # issue 4078:
   'allocation-site-info': [PASS, NO_VARIANTS],
 
diff --git a/test/mozilla/mozilla.status b/test/mozilla/mozilla.status
index d70c922b0d..1b096ec69a 100644
--- a/test/mozilla/mozilla.status
+++ b/test/mozilla/mozilla.status
@@ -73,6 +73,12 @@
   # TODO(mstarzinger): Investigate failure with lookup slot declaration.
   'js1_5/Regress/regress-343713': [PASS, NO_VARIANTS],
 
+  # Issue 4493: Open issues before we can ship general purpose inlining.
+  'js1_4/Eval/eval-002': [PASS, NO_VARIANTS],
+  'js1_5/Scope/regress-77578-001': [PASS, NO_VARIANTS],
+  'ecma_3/ExecutionContexts/10.1.3': [PASS, NO_VARIANTS],
+  'ecma_3/ExecutionContexts/regress-23346': [PASS, NO_VARIANTS],
+
   ############################ INVALID TESTS #############################
 
   # Function length properties are configurable in ES6
diff --git a/test/simdjs/simdjs.status b/test/simdjs/simdjs.status
index dba1681bdc..65c92be1a3 100644
--- a/test/simdjs/simdjs.status
+++ b/test/simdjs/simdjs.status
@@ -23,6 +23,9 @@
   # Slow tests.
   'benchmarks/kernel-template': [PASS, SLOW],
   'benchmarks/memset': [PASS, SLOW],
+
+  # Issue 4493: Open issues before we can ship general purpose inlining.
+  'shell_test_runner': [PASS, NO_VARIANTS],
 }],
 
 ######################################################################
diff --git a/test/webkit/webkit.status b/test/webkit/webkit.status
index be322c17dd..e54ca4852d 100644
--- a/test/webkit/webkit.status
+++ b/test/webkit/webkit.status
@@ -37,6 +37,8 @@
   'fast/js/deep-recursion-test': [PASS, NO_VARIANTS],
   # TODO(bmeurer,svenpanne): Investigate test failure.
   'fast/js/toString-number': [SKIP],
+  # Issue 4493: Open issues before we can ship general purpose inlining.
+  'call-apply-crash': [PASS, NO_VARIANTS],
 }],  # ALWAYS
 ['mode == debug', {
   # Too slow in debug mode.