diff --git a/BUILD.bazel b/BUILD.bazel
index 589f579c2c..be1aa33fe4 100644
--- a/BUILD.bazel
+++ b/BUILD.bazel
@@ -165,6 +165,7 @@ config_setting(
 # v8_control_flow_integrity
 # v8_enable_virtual_memory_cage
 # cppgc_enable_caged_heap
+# cppgc_enable_check_assignments_in_prefinalizers
 # cppgc_enable_object_names
 # cppgc_enable_verify_heap
 # cppgc_enable_young_generation
diff --git a/BUILD.gn b/BUILD.gn
index f4a0178005..cc6bdefc31 100644
--- a/BUILD.gn
+++ b/BUILD.gn
@@ -293,6 +293,10 @@ declare_args() {
   # Enables additional heap verification phases and checks.
   cppgc_enable_verify_heap = ""
 
+  # Enable assignment checks for Members/Persistents during prefinalizer invocations.
+  # TODO(v8:11749): Enable by default after fixing any existing issues in Blink.
+  cppgc_enable_check_assignments_in_prefinalizers = false
+
   # Enable allocations during prefinalizer invocations.
   cppgc_allow_allocations_in_prefinalizers = false
 
@@ -786,6 +790,10 @@ config("features") {
     defines += [ "CPPGC_VERIFY_HEAP" ]
   }
 
+  if (cppgc_enable_check_assignments_in_prefinalizers) {
+    defines += [ "CPPGC_CHECK_ASSIGNMENTS_IN_PREFINALIZERS" ]
+  }
+
   if (cppgc_allow_allocations_in_prefinalizers) {
     defines += [ "CPPGC_ALLOW_ALLOCATIONS_IN_PREFINALIZERS" ]
   }
diff --git a/src/heap/cppgc/pointer-policies.cc b/src/heap/cppgc/pointer-policies.cc
index a3718a183d..3c7cb61761 100644
--- a/src/heap/cppgc/pointer-policies.cc
+++ b/src/heap/cppgc/pointer-policies.cc
@@ -68,7 +68,7 @@ void EnabledCheckingPolicy::CheckPointerImpl(const void* ptr,
     DCHECK(!header->IsFree());
   }
 
-#ifdef CPPGC_VERIFY_HEAP
+#ifdef CPPGC_CHECK_ASSIGNMENTS_IN_PREFINALIZERS
   if (heap_->prefinalizer_handler()->IsInvokingPreFinalizers()) {
     // During prefinalizers invocation, check that |ptr| refers to a live object
     // and that it is assigned to a live slot.
@@ -81,7 +81,7 @@ void EnabledCheckingPolicy::CheckPointerImpl(const void* ptr,
     DCHECK(slot_is_live);
     USE(slot_is_live);
   }
-#endif  // CPPGC_VERIFY_HEAP
+#endif  // CPPGC_CHECK_ASSIGNMENTS_IN_PREFINALIZERS
 }
 
 PersistentRegion& StrongPersistentPolicy::GetPersistentRegion(
diff --git a/test/unittests/heap/cppgc/prefinalizer-unittest.cc b/test/unittests/heap/cppgc/prefinalizer-unittest.cc
index b0cd98cb28..3f01b5178f 100644
--- a/test/unittests/heap/cppgc/prefinalizer-unittest.cc
+++ b/test/unittests/heap/cppgc/prefinalizer-unittest.cc
@@ -292,7 +292,7 @@ class GCedHolder : public GarbageCollected<GCedHolder> {
 }  // namespace
 
 #if V8_ENABLE_CHECKS
-#ifdef CPPGC_VERIFY_HEAP
+#ifdef CPPGC_CHECK_ASSIGNMENTS_IN_PREFINALIZERS
 
 TEST_F(PrefinalizerDeathTest, PrefinalizerCantRewireGraphWithDeadObjects) {
   Persistent<LinkedNode> root{MakeGarbageCollected<LinkedNode>(
@@ -325,7 +325,7 @@ TEST_F(PrefinalizerDeathTest, PrefinalizerCantRessurectObjectOnHeap) {
   EXPECT_DEATH_IF_SUPPORTED(PreciseGC(), "");
 }
 
-#endif  // CPPGC_VERIFY_HEAP
+#endif  // CPPGC_CHECK_ASSIGNMENTS_IN_PREFINALIZERS
 #endif  // V8_ENABLE_CHECKS
 
 #ifdef CPPGC_ALLOW_ALLOCATIONS_IN_PREFINALIZERS
diff --git a/tools/cppgc/gen_cmake.py b/tools/cppgc/gen_cmake.py
index b4a805c07c..1063455b7f 100755
--- a/tools/cppgc/gen_cmake.py
+++ b/tools/cppgc/gen_cmake.py
@@ -245,6 +245,7 @@ set(CMAKE_CXX_STANDARD_REQUIRED ON)
 option(CPPGC_ENABLE_OBJECT_NAMES "Enable object names in cppgc for debug purposes" OFF)
 option(CPPGC_ENABLE_CAGED_HEAP "Enable heap reservation of size 4GB, only possible for 64bit archs" OFF)
 option(CPPGC_ENABLE_VERIFY_HEAP "Enables additional heap verification phases and checks" OFF)
+option(CPPGC_CHECK_ASSIGNMENTS_IN_PREFINALIZERS " Enable assignment checks for Members/Persistents during prefinalizer invocations" OFF)
 option(CPPGC_ENABLE_YOUNG_GENERATION "Enable young generation in cppgc" OFF)
 set(CPPGC_TARGET_ARCH "x64" CACHE STRING "Target architecture, possible options: x64, x86, arm, arm64, ppc64, s390x, mipsel, mips64el")
 
@@ -437,6 +438,9 @@ endif()
 if(CPPGC_ENABLE_VERIFY_HEAP)
   target_compile_definitions({target.name} PRIVATE "-DCPPGC_ENABLE_VERIFY_HEAP")
 endif()
+if(CPPGC_CHECK_ASSIGNMENTS_IN_PREFINALIZERS)
+  target_compile_definitions({target.name} PRIVATE "-DCPPGC_CHECK_ASSIGNMENTS_IN_PREFINALIZERS")
+endif()
 if(CPPGC_ENABLE_YOUNG_GENERATION)
   target_compile_definitions({target.name} PRIVATE "-DCPPGC_YOUNG_GENERATION")
 endif()"""